Antitussive indole alkaloids from Kopsia hainanensis.
نویسندگان
چکیده
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.
منابع مشابه
Kopsihainanines A and B, two unusual alkaloids from Kopsia hainanensis.
Kopsihainanine A (1), an unprecedented skeleton with a 6/5/6/6/6 pentacyclic rearranged ring system, together with a new biogenetically related compound, kopsihainanine B (2), were isolated from Kopsia hainanensis. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of 1 was determined by ECD calculation.
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عنوان ژورنال:
- Planta medica
دوره 77 9 شماره
صفحات -
تاریخ انتشار 2011